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6 cze 2024 · Intramuscular and intravenous thiamine can be used to prevent complications of alcohol dependence such as Wernicke’s encephalopathy.
18 mar 2023 · While clinical consequences of thiamine deficiency in alcohol use disorder (AUD) are severe, evidence-based recommendations on dosage, type of administration and duration of thiamine substitution (TS), and its’ target levels remain sparse.
1 mar 2020 · Given the potential benefit of preventing thiamine deficiency, oral thiamine supplementation is a consideration in the office management of alcohol use disorders and alcohol withdrawal.
Two randomised controlled trials examined differences in cognitive or neurological response to varied thiamine dose regimens for 1) treatment of acute Wernicke Korsakoff’s Syndrome and 2) the prevention of WKS in asymptomatic but at-risk patients.
Thiamine deficiency (vitamin B1) is common in patients with alcohol dependence. Cognitive impairments may be an early consequence of thiamine deficiency. Wernicke's encephalopathy is underdiagnosed and undertreated.
28 paź 2021 · Thiamine and magnesium supplementation are also commonly used during withdrawal to address nutritional deficiencies and prevent Wernicke encephalopathy.
18 lis 2004 · Specifically, the prophylactic treatment for at-risk patients consists of an intramuscular administration of 250 mg thiamine (plus other B vitamins and ascorbic acid), once daily for 3–5 consecutive days.
