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It is well known that chronic alcoholics are at high risk for being deficient in vitamin B1 (thiamine), which is known to put the patient at an increased risk for Wernicke-Korsakoff Syndrome, cerebellar degeneration, and cardiovascular dysfunction.
1 mar 2020 · Given the potential benefit of preventing thiamine deficiency, oral thiamine supplementation is a consideration in the office management of alcohol use disorders and alcohol withdrawal.
10 lip 2023 · The most common reason for thiamine deficiency is inadequate dietary intake. However, in Western countries, thiamine deficiency is more prevalent in individuals suffering from alcoholism or chronic illness. The symptoms of thiamine deficiency are non-specific.
Oral thiamine is ineffective in thiamine deficiency and should not be used in the initial treatment phase. The preferred route of thiamine administration is intravenous (IV), although intramuscular (IMI) route is acceptable if IV access cannot be obtained or continued.
Thiamine supplements are recommended for all people undergoing alcohol withdrawal (see ‘Wernicke–Korsakoff’s syndrome’ below). For patients with no clinical features of Wernicke’s encephalopathy or memory impairment, thiamine is recommended as a prophylactic measure.
18 lis 2004 · The present letter is intended to provide some element of discussion on thiamine dosage, route of administration and duration of treatment in alcoholics. The daily requirement of thiamine is ∼1.5 mg; on deprivation, TD occurs within 2–3 weeks ( Thomson, 2000 ).
7 wrz 2017 · The administration of intramuscular (IM) thiamine to ED patients with chronic alcoholism is a common and reasonable practice, however the subsequent initiation of outpatient thiamine supplementation is wildly variable, and the benefit of oral thiamine therapy (OTT) is unknown.
