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Patient brain scans show how proton therapy (left) targets brain tumors with minimal radiation going to surrounding tissue and structures, whereas traditional photon radiation (right) can damage surrounding brain tissues and structures.
The original rationale for proton therapy was the highly conformal depth-dose distributions that protons are able to produce, compared to photons, which allow greater sparing of normal tissues and escalation of tumor doses, thus potentially improving outcomes.
Too much radiation to the brain can cause neurological problems. Proton therapy precisely targets the tumor to minimize radiation to brain tissue, eyes, optic nerves, and the pituitary gland. This reduces the chance of secondary cancers and helps the patient keep better overall brain function.
Fractionated proton therapy led to five years excellent local control rates ranging from 88% to 100% . Fractionated proton therapy usually delivered 54–60 Gy(RBE) in five 1.8–2 Gy daily fractions per week to the tumour volume.
30 wrz 2024 · MSK radiation oncologist Dr. Yao Yu says proton therapy can control brain and spine tumors with less damage to normal tissue. The sophisticated form of radiation has recently proved effective in the treatment of leptomeningeal metastases.
Proton therapy, also known as proton beam therapy, is a radiation treatment that precisely delivers a beam of protons to disrupt and destroy tumor cells. Compared with traditional radiation, protons have unique properties that allow doctors to better target radiation to the size and shape of the tumor.
Proton Therapy / trends. Radiotherapy Dosage. Skull Base Neoplasms / diagnostic imaging. Skull Base Neoplasms / radiotherapy. This review details the indication of brain tumors for proton therapy and give a list of the open prospective trials for these challenging tumors.
