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8 lut 2017 · The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes into the two daughter cells during cell division, which is paramount for maintaining genome integrity....
30 sty 2018 · The mitotic spindle is a complex three-dimensional (3D) apparatus that functions to ensure the faithful segregation of chromosomes during cell division.
2 cze 2016 · The mitotic spindle is made of up to hundreds of thousands of microtubules (MTs) and roughly 1,000 MT-associated proteins (MAPs), of which ~200 are essential (22–25). Spindle MAPs can be grouped into several activity classes, namely MT nucleation, MT dynamics, MT transport, and MT cross-linking.
19 lip 2017 · Spindle microtubules attach to chromosomes via kinetochores, protein complexes assembled on the centromeres of each chromosome (Musacchio and Desai 2017). The central question in the field is how the cell achieves accurate chromosome segregation through interactions between kinetochores, microtubules, and the associated proteins.
25 sty 2021 · The life of a spindle starts with its formation by interactions between microtubules and chromosomes mediated by the microtubule-associated proteins and the kinetochore proteins during prometaphase and ends with chromosome segregation in anaphase, followed by spindle disassembly in telophase.
The mitotic spindle is an aesthetically attractive structure (Fig. 1 A). It is also a molecular machine capable of distributing the genome to the daughter cells with stunning precision. The spindle is built of microtubules that are used as tracks to move chromosomes precisely during cell division.
The mitotic spindle is a highly dynamic molecular machine composed of tubulin, motors, and other molecules. It assembles around the chromosomes and distributes the duplicated genome to the daughter cells during mitosis. The biochemical and physical principles that govern the assembly of this machine are still unclear.
