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1 paź 2012 · Microtubules are hollow cylindrical polymers that are assembled from heterodimers composed of α- and β-tubulin. The longitudinal orientation of the tubulin dimers provides microtubules with an intrinsic polarity, with α-tubulin facing the so-called minus end and β-tubulin the so-called plus end.
23 sie 2017 · Microtubule nucleation is stimulated and can be controlled by the following two principal activities: by providing a stable template (such as the γ-tubulin ring complex (γTuRC) or a severed...
1 sty 2014 · Microtubule (MT) is an essential cytoskeleton assembled from α- and β-tubulin dimers in all eukaryotic cells. MT nucleation requires γ-tubulin-containing ring complex in both animal and plant cells.
5 maj 2021 · Microtubules are hollow, cylindrical polymers formed from αβ-tubulin heterodimers that interact with each other in two ways: stronger head-to-tail (longitudinal) interactions between αβ-tubulins make up the straight protofilaments, and weaker side-to-side (lateral) interactions hold protofilaments together.
1 wrz 2017 · Microtubule nucleation, the formation of new microtubule filaments, begins from the minus end and is mostly dependent on γ-tubulin ring complexes (γ-TuRCs) in cells (Moritz and Agard, 2001). Importantly, nucleation by γ-TuRCs can be modulated by activators such as CDK5RAP2 ( Choi et al., 2010 ).
23 sie 2017 · In this Review, we will propose that various proteins — traditionally known as microtubule stabilizers — are as important as the γTuRC for controlling microtubule nucleation in cells, and we will...
Microtubule nucleation is the process in which several tubulin molecules interact to form a microtubule seed. Microtubule nucleation occurs spontaneously in purified tubulin solutions, and molecular intermediates between tubulin dimers and microtubules have been identified.
