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23 sie 2017 · Microtubule nucleation is stimulated and can be controlled by the following two principal activities: by providing a stable template (such as the γ-tubulin ring complex (γTuRC) or a severed...
10 paź 2011 · Microtubule nucleation is controlled by the γ-tubulin ring complex (γTuRC) and related γ-tubulin complexes, providing spatial and temporal control over the initiation of microtubule growth. Recent structural work has shed light on the mechanism of γTuRC-based microtubule nucleation, confirming the long-standing hypothesis that it functions ...
4 lip 2022 · Ongoing and future research in microorganisms will likely continue to reveal basic mechanisms for how tubulin isotypes facilitate MT functions, along with valuable perspectives on how they mediate the range of conserved and diverse processes observed across eukaryotic microbes.
1 paź 2012 · Microtubules provide tracks for the transport of molecules or organelles, mediate the segregation of chromosomes during meiotic and mitotic divisions, and serve as building blocks of flagella and motile cilia (Ishikawa and Marshall, 2011; Kapitein and Hoogenraad, 2011; Walczak and Heald, 2008).
Microtubule nucleation from centrosomes is mediated by γ-tubulin complexes, and it has been suggested that protein tyrosine kinases could modulate microtubule nucleation in activated mast cells [27,28,29].
30 cze 2009 · It stabilizes microtubules in vivo and stimulates spontaneous microtubule nucleation and growth in vitro (up to two times faster than tubulin alone). It promotes both catastrophes and rescues. EB1 dynamically tracks growing microtubule plus ends via multiple rounds of association at the newly growing end and rapid dissociation from the older ...
12 paź 2011 · Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-tubulin complexes, providing spatial and temporal control over the initiation of microtubule growth.
