Search results
12 lut 2016 · In vitro and in vivo animal models are important tools in cancer research, enabling the identification of carcinogens, the development of cancer therapies, drug screening, and providing insight into the molecular mechanisms of tumor growth and metastasis.
8 kwi 2020 · The choice of the correct tumor model at the stage of in vitro testing provides reduction in both financial and time costs during later stages due to the timely screening of ineffective agents.
7 wrz 2023 · During the preclinical stage, the screening of multiple compounds is performed with in vitro and in vivo platforms, including animal testing. Two-dimensional (2D) cell cultures are widely used in the preclinical stage to study the efficacy of cancer drugs, where cells are methodically exposed to therapeutic compounds and their responses are ...
16 lut 2023 · This chapter reviews blood-based cancer biomarkers, circulating tumor DNA (ctDNA), cancer-released exosomes and proteins, and circulating tumor cells (CTCs), and their role in cancer screening, diagnosis, and post-diagnosis follow-up and prognosis prediction.
20 gru 2021 · A precision diagnostic platform integrating genomics and transcriptomics with drug testing of patient's primary tumor cells in high throughput drug screening (HTS) and patient‐derived xenograft (PDX) was established to improve identification of therapies in high‐risk pediatric cancer patients.
28 maj 2021 · Therefore, an accurate, cost-effective, and non-invasive test for multiple major cancer screening is in high demand. We previously reported a cfDNA methylation test, which can detect five major cancer types with high specificity and sensitivity, especially at the early stage (stage I).
Realistic in vitro models of tumors enable more detailed primary screening of potential antitumor drugs thus preventing drugs with insufficient antitumor activity from entering preclinical animal testing.
