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1 sie 2023 · Histiocytosis is a rare group of conditions that occur when your body makes abnormal (mutant) white blood cells called histiocytes. Normal histiocytes help tune up your body’s defenses against multiple pathogens (like viruses, bacteria, fungi and parasites).
29 sie 2018 · Langerhans-cell histiocytosis (LCH), the most common histiocytic disorder, encompasses conditions characterized by aberrant function and differentiation or proliferation of cells of the...
Histiocytosis, also referred to as Langerhans Cell Histiocytosis (LCH), and formally called Histiocytosis X, represents a group of rare disorders involving specific cells that normally have important roles as part of the immune system.
Endocrinologists are more familiar with the term histiocytosis X, which includes three related disorders: solitary bony disease (eosinophilic granuloma), Hand-Schüller-Christian disease (chronic disease with diabetes insipidus, exophthalmos, and multiple calvarial lesions), and disseminated histiocytosis X (Letterer-Siwe disease, with widespread...
1 mar 1987 · Histiocytosis-X: An Overview Michael E. Osband, MD, * and Carl Pochedly, MD\ The goal of this issue is to include in a single volume the diverse body of knowledge related to our current understanding of histiocytosis-X.
In this Review, we describe insights into the cells of origin, molecular pathology, clinical features, and treatment strategies for some of the most common histiocytic disorders, including Langerhans cell histiocytosis, Erdheim-Chester disease, and Rosai-Dorfman disease.
16 kwi 2020 · Langerhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors that differentiate into CD1a + /CD207 + cells in lesions that leads to a spectrum of organ involvement and dysfunction. The pathogenic cells are defined by constitutive activation of the MAPK signaling pathway.
