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The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
21 lip 2023 · The first pass effect is a crucial aspect of drug metabolism and bioavailability. Understanding its mechanism, factors influencing it, and its implications for drug therapy can guide healthcare professionals in optimizing drug dosing and selection to ensure optimal therapeutic outcomes.
This metabolism, which occurs before oral drugs are able to reach the systemic circulation, is known as first-pass metabolism. Drugs with significant first-pass metabolism include morphine, lidocaine, glyceryl trinitrate and salbutamol.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
Before an orally absorbed drug reaches systemic circulation, it must first pass through the intestine, and then the liver where drug metabolism known as pre-systemic metabolism may occur. This is known more commonly as the first-pass effect.
30 lip 2023 · The liver is the site of first-pass metabolism. The bioavailability of a drug will be reduced proportionally to the fraction of the initial dose converted to inactive metabolites by liver enzymes. Notably, hepatic cytochrome P450 metabolism can significantly alter drug bioavailability.
