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What is first pass metabolism? This occurs when drug molecules in the stomach and intestines are diverted into the hepatic portal circulation before they have a chance to enter the systemic circulation.
- First pass metabolism Flashcards
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- First pass metabolism Flashcards
What is the first-pass effect? The initial metabolism in the liver of a drug absorbed from the gastrointestinal tract before the drug reaches systemic circulation through the bloodstream 1 / 28
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The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.
Show me the answers! Question 1 Medicines administered orally are absorbed through the GI tract into the bloodstream. Blood travels immediately to the liver where some drugs are inactivated the first time they pass through e.g. GTN is given sublingually to avoid first pass.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
