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3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
1 sty 2018 · Easily performed drug metabolism (in vitro) investigations serve as a suitable screening mechanism to identify drug metabolites and explain their pathways for further examinations (in vivo).
1 sty 2018 · The first-pass metabolism of a drug mainly in the gastrointestinal tract (GIT) and liver is considered as an almost unavoidable obstacle that can greatly reduce the systemic bioavailability as well as the efficacy of an orally administered drug.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
first-pass metabolism via sulfate conjugation of phenyle-phrine, comparisons are drawn with four drugs: ibopamine, budesonide, methyldopa and acetaminophen [5–8]. The disposition of ibopamine is predominantly governed by phase 2 metabolism involving sulfate conjugation, and the saturability of the formation of the phase 2 metabolite has
Knowledge of first pass metabolism can assist the prescriber when deciding on doses and dose schedules to ensure that patients receive their medications at the correct dosing, by the correct route for optimum therapeutic effect.
The first-pass effect has been a basic tenant of pharmacology but an area not receiving active research interest and one that is often overlooked in the clinical arena. Avoiding drug interactions is a consideration, and that is a major challenge to the field of clinical pharmacology.
