Search results
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
30 lip 2023 · The liver is the site of first-pass metabolism. The bioavailability of a drug will be reduced proportionally to the fraction of the initial dose converted to inactive metabolites by liver enzymes. Notably, hepatic cytochrome P450 metabolism can significantly alter drug bioavailability.
Before an orally absorbed drug reaches systemic circulation, it must first pass through the intestine, and then the liver where drug metabolism known as pre-systemic metabolism may occur. This is known more commonly as the first-pass effect.
First-pass metabolism refers to the process where a drug is metabolized, or broken down, by the liver and other organs before it reaches the systemic circulation and becomes available to the rest of the body.
The first-pass effect plays a crucial role in determining drug choice and dosing strategies in clinical settings. Medications with a high first-pass metabolism may require higher oral doses to achieve effective serum concentrations.
