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3 sie 2024 · Distal muscular dystrophy (DD), also called distal myopathy, is not one disorder, but a group of genetic disorders under the larger umbrella of muscular dystrophy. DD is marked by progressive weakness and/or wasting of the voluntary distal muscles.
Distal myopathies comprise a rare and heterogeneous group of disorders that present with weakness of the distal muscles of the hands, feet, or both. 1 The term distal myopathy is usually reserved for genetic disorders, although weakness of distal muscles is sometimes prominent in the acquired muscle diseases. 2 In addition, prominent distal ...
15 sty 2020 · Weakness is the predominant feature of primary muscle disorders, or myositides. Some of these disorders, such as dermatomyositis, polymyositis, and necrotizing myositis, present with acute...
Typically, the first symptom of distal muscular dystrophy (DD) is weakness in the distal muscles — those farthest away from the hips and shoulders such as those in the hands, feet, lower arms or lower legs. With time, other muscle groups may become affected as well.
Weakness is first seen in the leg and neck muscles, and progresses slowly to include upper leg muscles, hands and more neck muscles. Gowers-Laing distal myopathy results from mutations in the MYH7 gene, which instructs for myosin heavy chain 7, a protein that participates in muscle contraction.
Myopathy is a general term that refers to diseases that affect the muscles that connect to your bones (skeletal muscles). Myopathies may be passed on in families (inherited) or they may develop later in life (acquired).
