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20 maj 2020 · Basic science discoveries elucidating the molecular and cellular biology of the T cell have led to new strategies in this fight, including checkpoint blockade, adoptive cellular therapy and...
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25 wrz 2023 · Vector-based cancer immunotherapy involves using modified viruses, or vectors, to deliver therapeutic agents directly to cancer cells. The vectors are engineered to target specific cancer cells and trigger an immune response, which helps the body's natural defenses fight the cancer.
15 kwi 2021 · Several of these vectors are being developed for diverse applications such as immunotherapy, suicide gene therapy , microRNA (miRNA) targeted therapy, chimeric antigen receptor (CAR)-T cell ...
4 mar 2020 · Immune responses are a major determinant for the outcome of gene and cell therapies. For instance, the innate and adaptive arms of the immune system may respond to components of the vector or its gene products or eliminate cells producing the therapeutic protein, thus causing loss of therapy and/or immunotoxicities.
19 wrz 2022 · In this article, we will discuss different strategies for cancer immunotherapy, including IC- and stimulatory molecule-targeted agents, cellular immunotherapy, and suppressive TME-targeting ...
30 sty 2024 · Vectors are essentially vehicles designed to deliver therapeutic genetic material, such as a working gene, directly into a cell. There are four main types of viral vectors (adeno-associated viral, adenoviral, lentiviral, retroviral) each with their own unique characteristics, uses, and limitations.
Immunotherapies are a form of biological therapy (Biological Response Modifier (BRM) therapy) as they contain materials from residing organisms to combat opposition to most cancer cells. Some immunotherapies make use of genetic engineering techniques to enhance immune surveillance against neoplastic cells in the body.