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10 mar 2022 · Multiple strategies have emerged, and several potent agents that reduce AR protein levels were reported to eliminate xenograft tumor growth in preclinical models via distinct mechanisms, including proteasome-mediated degradation, heat-shock protein inhibition, AR splicing suppression, blockage of AR nuclear localization, AR N-terminal suppression.
21 lip 2022 · Prostate cancer is a hormone-dependent malignancy, whose onset and progression are closely related to the activity of the androgen receptor (AR) signaling pathway. Due to this critical role of AR...
28 sie 2019 · These cancers are androgen ablation resistant, clinically termed castration resistant prostate cancer (CRPC) and remain incurable. First-generation antiandrogens established androgen receptor blockade as a therapeutic strategy, but these therapies do not completely block androgen receptor activity.
21 sie 2018 · Androgen receptor antagonist ARN-509 with or without Abiraterone Acetate, gonadotropin-releasing hormone analog, and Prednisone in treating patients with high-risk prostate cancer...
25 mar 2021 · The Androgen Receptor and Tumor Microenvironment in Prostate Cancer Classified as a steroid hormone receptor, the AR is a ligand-activated nuclear transcription factor whose role is the regulation of target gene expression.
3 lip 2024 · UBX-390 suppresses chromatin binding and gene expression of AR and demonstrates substantial efficacy in the degradation of AR mutants in patients with treatment-resistant prostate cancer. UBX-390 is presented as an optimized AR degrader with remarkable potential for treating castration-resistant prostate cancer.
19 mar 2021 · The introduction of second-generation androgen receptor antagonists (SG-ARAs) has greatly impacted the treatment of metastatic prostate cancer, providing tolerable and efficacious...
