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16 lut 2018 · Sickle-cell trait is the heterozygous form of sickle-cell disease, a hereditary blood disorder caused by a single mutation of the β-globin gene, resulting in the production of abnormal haemoglobin called haemoglobin S (HbS). 1 Although sickle-cell disease results in a range of painful complications, sickle-cell trait is generally asymptomatic ...
One of the most common hemoglobinopathies is hemoglobin S, the sickle cell gene. In a severe form of sickle cell disease, sickle cell anemia, a patient inherits two genes for hemoglobin S. Patients can also inherit one sickle cell gene and have sickle cell trait, often with no signs or symptoms.
Information about the effect of hemoglobin variants, called hemoglobinopathies, and sickle cell trait on the detection of diabetes using the A1C test.
Having sickle cell trait or another hemoglobin variant does not increase a person’s risk for developing diabetes. In sickle cell disease, a person inherits two genes for hemoglobin S, which causes the malformation, or sickling, of red blood cells, leading to anemia, repeated infections, and periodic episodes of pain.
Learn why to tell your doctor about your trait status and how it might affect your A1C test results.
2 lis 2023 · Background: Approximately 10% of adults with sickle cell disease (SCD) have diabetes mellitus (DM) (PMID 30714090). Glycemic control is challenging to evaluate in the setting of hemoglobinopathies, such as SCD, due to potentially inaccurate hemoglobin A1c (HbA1c) measurements (PMID 30897962).
Sickle-cell trait and diagnosis of type 2 diabetes. Lancet Diabetes Endocrinol. 2018 Nov;6 (11):840-843. doi: 10.1016/S2213-8587 (18)30033-0. Epub 2018 Feb 17. Authors. Sarah Skinner 1 , Vincent Pialoux 2 , Bérengère Fromy 3 , Dominique Sigaudo-Roussel 3 , Philippe Connes 4. Affiliations.
