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10 sie 2020 · In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the Ig diversification process, which comprises somatic hypermutation and class switch recombination; and (iii) consequences of cytosine deamination in other than the Ig loci, in ...
24 lut 2023 · Uracil is a base analogue of thymine and is found in both DNA and RNA (Figure 1). As a pyrimidine nucleotide it has an amino acid group at the 2′ position and a carboxy group at the 5′ position. U and T are equivalent in their information storage, transmission and their base pairing with adenine.
In DNA, the evolutionary substitution of thymine for uracil may have increased DNA stability and improved the efficiency of DNA replication (discussed below). Uracil pairs with adenine through hydrogen bonding. When base pairing with adenine, uracil acts as both a hydrogen bond acceptor and a hydrogen bond donor.
28 wrz 2010 · The finding that extra-helical U can develop spontaneously from an intermediate open U–A base pairs combined to the U–A versus T–A sequence dependence of base pair opening kinetics derived from NMR experiments, has important implications in the repair efficiency shown by UDGs.
5 cze 2008 · The common RNA base uracil (U) that is substituted by thymine (T) in DNA is able to naturally pair with adenine (A) but can also mispair with guanine (G). The U:A pair in DNA results from the incorporation of dUTP by polymerases and constitutes a non-mutagenic event per se that can nonetheless alters promoters functions [ 1 ].
discovered, DNA forms a double helix in which the four bases always pair up the same way, through specif-ic hydrogen bonds: adenine binds to thymine, and guanine to cytosine (see Figures 2 and 3). There is an alternative fifth letter, though: uracil (U), which forms the same pattern of hydrogen bonds with adenine (see Figure 4). But although.
1 gru 2010 · Based on the literature data we conclude/hypothesize that the non-canonical base uracil may be present and well tolerated in DNA mostly as U:A pairs, likely in quantities of 10 4 per genome.
