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12 sty 2023 · In this study, we identify the deacetylase SIRT1 as the key determinant of sensitivity to the WEE1 inhibitor MK-1775. SIRT1-deficient cells resist high doses of MK-1775, which we show is due to the...
Wee1 is a tyrosine kinase that inhibits the activation of CDK1 and CDK2 to protect genomic integrity by regulating initiation of replication.
3 cze 2023 · The discovery of the WEE1 inhibitor AZD1775 further emphasized WEE1 as a promising anticancer target. Therefore, the current review provides a comprehensive data on medicinal chemistry, synthetic approaches, optimization methods, and the interaction profile of WEE1 kinase inhibitors.
13 gru 2021 · In this in silico study, we assessed the structural conservation of the WEE1 protein in the plant kingdom with a particular focus on agronomically valuable plants, the legume crops.
19 wrz 2024 · Different from biochemistry, which studies the chemistry within biological systems, chemical biology aims to study and manipulate biological systems at a molecular level using chemical tools and technologies.
Biological sciences encompasses all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and...
Undergraduates in the Peeler Lab gain experience in a number of chemical biology and biochemistry techniques, including molecular cloning, tissue culture, protein expression and purification, and enzyme assays.
