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8 maj 2018 · The guidelines suggested treatment of vitamin D deficiency with 50,000 international units (IU) weekly or its equivalent of 6,000 IU daily to achieve a blood level of 25(OH)D >30 ng/mL (75 nmol/L), followed by a maintenance dose of 1,500 to 2,000 IU/day.
Some examples of published regimens for the correction of vitamin D status in healthy adults include 50,000 IU of ergocalciferol once a week for 8 weeks (12) or 50,000 IU of ergocalciferol twice a week for 5 weeks (13). Furthermore, there are limited data to evaluate the efficacy of various methods of correction of vitamin D status in adults.
Vitamin D3 therapy (50,000-100,000 IU/week) was safe and effective when given for 12 months to reverse statin intolerance in patients with vitamin D deficiency. Serum vitamin D rarely exceeded 100 ng/mL, never reached toxic levels, and there were no significant change in serum calcium or eGFR.
In most studies, cholecalciferol and ergocalciferol were used, with significant heterogeneity across them. Doses ranged from 800 IU daily to 50,000 IU twice weekly. Serum PTH decreased on average by 33% (p=0.003) . Adequate levels of vitamin D in PHPT will help to control any tendency for PTH levels to rise further, if 25(OH)D levels fall below ...
Those receiving 50,000 IU D2 twice weekly displayed the most rapid and robust response, with 25(OH)D reaching >30 ng/mL (>75 nmol/L) after only 1 month and plateauing at 60 ng/mL (150 nmol/L) by 7 months.
The average intact parathyroid hormone levels were 24.2 pg/ml (D3) vs. 30.2 pg/ml (no D3). In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe.
In the most recent guidelines on the management of vitamin D deficiency in adults, the Endocrine Society recommends a regimen of once weekly 50,000 IU ergocalciferol or cholecalciferol for eight weeks or 6,000 U/day for eight weeks, followed by a daily dose of 1500-2000 IU as maintenance therapy.
