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Thiamine, also known as vitamin B1, is normally produced by bacteria in the rumen of cattle and sheep on well-balanced roughage diets. Thiamine deficiency reduces energy availability to the brain, which leads to a type of brain degeneration called polioencephalomalacia or PEM.
The most common cause of PEM is thiamine deficiency. Thiamine is a B vitamin (vitamin B1) that plays a critical role in all cells, acting as a cofactor for several key enzymes involved in glucose metabolism.
Polioencephalomalacia (PEM) is an important neurologic disease of ruminants that is seen worldwide. Cattle, sheep, goats, deer, and camelids are affected. PEM is a pathologic diagnosis and a common end point of several conditions.
1 sty 2020 · Diets containing high levels of fermentable-starch or sulphur, and/or ingestion of moldy feed containing high levels of thiaminases can further increase the incidence and severity of B1 deficiency in sheep leading to the commonly observed condition of polioencephalomalacia [26], [27].
Injectable thiamine (vitamin B1) is highly effective at rapidly reversing signs, if given early and in massive doses. Intravenous products are available and should be administered slowly. Dexamethasone may be useful to decrease oedema and inflammation of the brain.
25 wrz 2018 · The most common cause of PEM is thiamine deficiency. Thiamine is a B vitamin (vitamin B1) that plays a critical role in all cells, acting as a cofactor for several key enzymes involved in glucose metabolism.
As a precursor for a universal metabolic coenzyme, vitamin B1, also known as thiamine, is a vital nutrient in all living organisms. We previously found that high-dose thiamine therapy prevents overnutrition-induced hepatic steatosis in sheep by enhancing oxidative catabolism.
