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Vulval (or vulvar) intraepithelial neoplasia is a pre-cancerous skin lesion (a type of squamous cell carcinoma in situ) that can affect any part of the vulva. The term vulval intraepithelial neoplasia describes two conditions with different biological behaviour: usual type and differentiated type.
25 lip 2024 · VaIN is defined by the presence of squamous cell atypia without invasion. The disease is classified according to the depth of epithelial involvement: VaIN 1 and 2 involve the lower one-third and two-thirds of the epithelium, respectively (picture 1). VaIN 3 involves more than two-thirds of the epithelium.
There are two types of vulvar intraepithelial neoplasia (VIN): usual VIN and differentiated or simplex-type VIN (dVIN) uVIN is driven by human papilloma virus (HPV) infection, occurs in young women, is characterized by hyperchromatic nuclei, increased mitotic figures, increased nuclear to cytoplasmic ratios and overexpresses p16.
The ISSVD recommends the terms low-grade squamous intraepithelial lesion of the vulva (vulvar LSIL) and high-grade squamous intraepithelial lesion of the vulva (vulvar HSIL) for histopathologic diagnoses of productive HPV infections, which includes external genital warts and precancer, respectively.
18 paź 2023 · VaIN 1 (mild dysplasia, or low-grade VaIN): Abnormal cells are located only in the outermost third of the vagina lining's thickness. VaIN 2 (moderate dysplasia, or high-grade VaIN): Abnormal cells have spread deeper and can now be found in two-thirds of the vaginal lining's thickness.
24 lip 2023 · VIN 2 means that the abnormal growth has a depth of less than two-thirds of the top layer of vulvar skin. Not everyone has symptoms of VIN 2. It’s sometimes diagnosed because it’s found...
29 mar 2023 · Vulval intraepithelial neoplasia or VIN is when abnormal cells develop in the top layer of skin covering the vulva. It is not vulval cancer but could turn into cancer. This may take many years.
