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Chlorambucil is the most effective drug evaluated for the treatment of CLL in dogs and cats. A combined protocol with chlorambucil and prednisone showed a better antitumor activity in humans. Although complete remissions are rare, survival times vary among 1 to 3 years with a good quality of life.
Removal of the tumour should result in resolution of skin lesions, and recurrence of the cancer causes a relapse of the dermatosis. In some cases, disease morbidity and effects on quality of life are more due to the paraneoplastic effects than the primary tumour.
uVIN/HSIL and d-VIN are treated to reduce the risk of developing invasive cancer and to alleviate symptoms. What treatments are available for uVIN/HSIL? The aim is to remove all affected tissue with a margin of apparently unaffected tissue.
Most cases of VIN can be cured with proper treatment and follow-up. If left untreated, VIN can progress to vulvar cancer. Although vulvar cancer is rare, VIN is becoming more common.
29 mar 2023 · Your doctor may suggest you have monitoring instead of treatment straight away. This is usual for low grade squamous intraepithelial lesion (LSIL) or VIN 1. You usually have treatment for high grade squamous intraepithelial lesion (HSIL) and differentiated VIN. Treatment includes: surgery; treatment with a cream called imiquimod; laser treatment
Treatment options for VIN include surgical excision, laser ablation, and topical treatment with imiquimod. In many women, a combination of these modalities is used. Retrospective data have shown that approximately 30% of patients treated for VIN develop recurrent disease, irrespective of treatment modality used.
When occult invasion is not a concern, vulvar HSIL (VIN usual type) can be treated with excision, laser ablation, or topical imiquimod (off-label use). Women with vulvar HSIL (VIN usual type) are at risk of recurrent disease and vulvar cancer throughout their lifetimes.
