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Variola virus forms the characteristic pus-filled pustules and centrifugal rash dis-tribution in the infected patients while trans-mission occurs mainly through respiratory droplets during the early stage of infection. No antiviral drugs are approved for variola virus till date.
Variola Virus. Variola is a human-specific virus. Generally it can be readily distinguished from other orthopoxviruses capable of infecting man (vaccinia, cowpox, monkeypox) by the characteristic small white pocks produced on the chorioallantoic membrane of developing 12-to 15-day-old chick embryos and the ceiling temperature of growth. How ...
The pathogenesis of smallpox has been studied in three ways: (1) by using material from human patients; (2) by conducting experiments with variola virus infection of nonhuman primates; and (3) by conducting experiments with model infections in mice, rabbits, and monkeys using related orthopoxviruses.
The variola virus is a large, brick-shaped, double-stranded DNA virus that serologically cross-reacts with other members of the poxvirus family, including ectromelia, cowpox, monkeypox,...
This is a transmission electron microscopic (TEM) image of a tissue section containing variola virus particles, the pathogen responsible for causing smallpox in humans. These organisms display an internal, dumbbell-shaped structure that represents the viral core containing the viral DNA.
3 maj 2019 · Variola virus (VARV), the etiological agent of smallpox, is a historical cause of immense morbidity and mortality that resulted in an estimated 300–500 million deaths in the twentieth century alone.
28 maj 2024 · Variola virus forms the characteristic pus-filled pustules and centrifugal rash distribution in the infected patients while transmission occurs mainly through respiratory droplets during the early stage of infection. No antiviral drugs are approved for variola virus till date.
