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Variola virus forms the characteristic pus-filled pustules and centrifugal rash dis-tribution in the infected patients while trans-mission occurs mainly through respiratory droplets during the early stage of infection. No antiviral drugs are approved for variola virus till date.
- SpringerLink
We have clearly made progress in our understanding of...
- SpringerLink
28 maj 2024 · We have clearly made progress in our understanding of variola virus transmission, life cycle, host limitation and viral species-dependent pathology despite restrictions on scientific study with infectious viruses.
Variola Virus. Variola is a human-specific virus. Generally it can be readily distinguished from other orthopoxviruses capable of infecting man (vaccinia, cowpox, monkeypox) by the characteristic small white pocks produced on the chorioallantoic membrane of developing 12-to 15-day-old chick embryos and the ceiling temperature of growth. How ...
The vires spreads to different organs of the host and in this process causes tissue damage. Strains of a virus (e.g., variola major and variola minor) differ in their vimlence or ability to cause fatal disease.
Poxviruses comprise a large family of viruses characterized by a large, linear dsDNA genome, a cytoplasmic site of replication and a complex virion morphology. The most notorious member of the poxvirus family is variola, the causative agent of smallpox.
Variola Virus Research (ACVVR), which was established in 1999, oversees all research using live variola virus, based on the World Health Assembly decisions contained in WHA49.10, WHA52.10 and WHA 55.15.
3 maj 2019 · Variola virus (VARV), the etiological agent of smallpox, is a historical cause of immense morbidity and mortality that resulted in an estimated 300–500 million deaths in the twentieth century alone. However, in vitro and in vivo investigations with infectious...
