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Variola Virus. Variola is a human-specific virus. Generally it can be readily distinguished from other orthopoxviruses capable of infecting man (vaccinia, cowpox, monkeypox) by the characteristic small white pocks produced on the chorioallantoic membrane of developing 12-to 15-day-old chick embryos and the ceiling temperature of growth. How ...
Variola virus forms the characteristic pus-filled pustules and centrifugal rash dis-tribution in the infected patients while trans-mission occurs mainly through respiratory droplets during the early stage of infection. No antiviral drugs are approved for variola virus till date.
The vires spreads to different organs of the host and in this process causes tissue damage. Strains of a virus (e.g., variola major and variola minor) differ in their vimlence or ability to cause fatal disease.
3 maj 2019 · Variola virus (VARV), the etiological agent of smallpox, is a historical cause of immense morbidity and mortality that resulted in an estimated 300–500 million deaths in the twentieth century alone.
28 maj 2024 · Variola virus forms the characteristic pus-filled pustules and centrifugal rash distribution in the infected patients while transmission occurs mainly through respiratory droplets during the early stage of infection. No antiviral drugs are approved for variola virus till date.
Before eradication was declared in 1980, the Orthopoxvirus (OPV) variola virus (VARV) caused from ∼1 to 30% case-fatality rates (CFRs) of smallpox, a strictly human disease. The infection began with a prodrome of systemic aches and a fever that peaked in about a week.
Archaeovirology efforts provided a rich portrait of the evolutionary history of variola virus (VARV, the cause of smallpox), which was characterized by lineage extinctions and a relatively recent origin of the virus as a human pathogen (~1700 years ago, ya).
