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What are vancomycin levels? Vancomycin serum trough concentrations, levels drawn just before the next scheduled dose, are considered the most practical method for monitoring efficacy when the pathogen is susceptible. 2 Vancomycin peak concentrations, levels from blood specimens obtained 30 to 60 minutes after drug administration, aren't ...
- Optimal Practice for Vancomycin Therapeutic Drug Monitoring ... - LWW
For many years, dose individualization of vancomycin in...
- Optimal Practice for Vancomycin Therapeutic Drug Monitoring ... - LWW
6 lut 2021 · This systematic review and meta-analysis identified trough concentrations and AUC values of VCM associated with its effectiveness and safety. Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed higher potential to reduce the incidence of VCM-induced AKI.
1 kwi 2019 · Current consensus guidelines recommend measuring trough vancomycin concentrations during intermittent dosing as a surrogate for the AUC 24. Trough concentrations are a misleading surrogate for AUC 24 and a poor end-point in themselves.
For many years, dose individualization of vancomycin in routine clinical practice has been based solely on the assessment of trough concentrations. 17 The recently updated US consensus guidelines strongly recommend that vancomycin TDM be based exclusively on the assessment of 24-hour AUC (AUC 24) to better achieve clinical efficacy and ensure ...
1 sie 2009 · Trough serum vancomycin concentrations are the most accurate and practical method of monitoring the effectiveness of vancomycin. Trough serum concentrations should be obtained just before the fourth dose, at steady-state conditions.
Minimum serum vancomycin trough concentrations should always be maintained above 10 mg/L to avoid development of resistance. For a pathogen with an MIC of 1 mg/L, the minimum trough concentration would have to be at least 15 mg/L to generate the target AUC:MIC of 400. IIIB Therapeutic vancomycin drug monitoring, Optimal trough concentrations
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough...
