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22 lut 2023 · A comprehensive guide for vancomycin dosing based on pharmacodynamic targets, renal function, and indication. Includes loading dose, maintenance dose, dose adjustment, and discharge criteria for intermittent and continuous infusion.
2 sie 2024 · Learn about vancomycin dosing, monitoring, and adverse effects in adults with invasive gram-positive infections. Compare different guidelines on therapeutic monitoring published by various professional societies and agencies.
23 gru 2020 · The guideline recommendations involve a broadened range of patients requiring TDM, modified index of TDM (both 24-hour area under the curve and trough concentration), addition regarding the necessity and timing of repeated TDM, and initial dose for specific subpopulations.
This consensus review evaluates the scientific data and controversies associated with serum vancomycin monitoring and provides recommendations based on the available evidence. It covers vancomycin pharmacokinetics, pharmacodynamics, efficacy, resistance, and toxicity in adult patients.
Monitoring should begin within 48 hours of therapy. Vancomycin AUC and trough concentrations should be less than 800 μg × h/mL over 24 hours and 15 μg/mL, respectively, to minimize acute kidney injury (evidence quality: A-II). All the recommendations for pediatrics are new for the updated guideline.
1 sie 2009 · Trough serum vancomycin concentrations are the most accurate and practical method of monitoring the effectiveness of vancomycin. Trough serum concentrations should be obtained just before the fourth dose, at steady-state conditions.
For many years, dose individualization of vancomycin in routine clinical practice has been based solely on the assessment of trough concentrations. 17 The recently updated US consensus guidelines strongly recommend that vancomycin TDM be based exclusively on the assessment of 24-hour AUC (AUC 24) to better achieve clinical efficacy and ensure ...
