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In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is acceptable in a patient receiving every 8- or 12-hour dosing.
22 lut 2023 · SHC Vancomycin Dosing Guide. A: Initial dosing considerations. B. Pharmacodynamic Targets: goal AUC and troughs. C. Loading dose. D: Initial Vancomycin Maintenance Dosing and Serum Concentration Monitoring. E: Dose Revisions. F: Intermittent Hemodialysis Dosing Algorithms. G: Continuous Infusion Vancomycin. H: PK equations.
2 cze 2016 · Troughs should be drawn about 30 minutes prior to the next dose. Quick side note. ALWAYS make sure the trough was drawn at the correct time before reacting to it.
Why & How to Monitor Vancomycin Troughs? Vancomycin is a glycopeptide antibiotic, typically used for treatment of MRSA. Traditionally it is recommended to get trough doses to assess efficiency. Typically, we aim for Vancomycin trough levels between 10-20µg/mL (15-20 µg/mL for more severe infections). WHY NOT MEASURE PEAKS?
Vancomycin is an antibiotic widely used for severe gram-positive infections, especially in the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA), which can lead to more than 20% mortality. 1 Therapeutic drug monitoring is essential for patients receiving vancomycin therapy to ensure that serum concentrations ar...
One of the biggest changes from the last vancomycin dosing guideline published in 2009 is that experts recommend moving from dosing based on trough to dosing based on area under the curve (AUC) for adults and pediatrics who have suspected or definitive serious MRSA infections.
2 sie 2024 · The optimal approach to vancomycin dosing and monitoring for invasive methicillin-resistant S. aureus (MRSA) infections is a subject of ongoing controversy and study. Challenges include how best to optimize clinical efficacy (particularly in the setting of emerging resistance) while minimizing toxicity (primarily nephrotoxicity) [ 6-9 ].
