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In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is acceptable in a patient receiving every 8- or 12-hour dosing.
Two drug levels available (peak and trough): This is the most accurate method of calculating a patient-specific CL vanco and Vd; however, it requires two drug levels to be drawn. These patient-specific pharmacokinetic values can be calculated using the Sawchuk-Zaske method .
2 sie 2024 · Learn how to optimize vancomycin therapy for invasive gram-positive infections, including MRSA, based on guidelines and literature review. Find out how to monitor vancomycin serum concentrations and adjust dosing based on kidney function and pathogen susceptibility.
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough...
Typically, we aim for Vancomycin trough levels between 10-20µg/mL (15-20 µg/mL for more severe infections). WHY NOT MEASURE PEAKS? Vancomycin displays time-dependent bactericidal activity when above the minimum inhibitory concentration (MIC), not dose-dependent.
16 sty 2019 · Learn how to optimize vancomycin dosing and levels for critically ill patients with MRSA infections. The web page explains why trough levels are inadequate and how to use AUC and Vd to achieve the best outcomes.
Vancomycin troughs of 15-20 μg/mL should approximate an AUC/MIC of 400 mg·h/L. The ideal PD goal for Gram positives organisms other than S. aureus, has not been defined. Toxicity. Nephrotoxicity is reported ≤ 5% of cases. Risk factors include: . Doses > 4g/day . Actual body weight ≥ 101.4 kg.
