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14 lut 2022 · Insulin resistance (IR) plays an important role in the pathophysiology of PCOS; therefore, its treatment may benefit women with the syndrome. The main drug used for IR management is metformin (MT). We aim to review the literature on the use of metformin in women with PCOS.
15 kwi 2014 · Metformin is an effective ovulation induction agent for non-obese women with PCOS and offers some advantages over other first line treatments for anovulatory infertility such as clomiphene. For clomiphene-resistant women, metformin alone or in combination with clomiphene is an effective next step.
20 lis 2023 · Metformin is recommended for anthropometric and metabolic outcomes, with best evidence in women with BMI ≥25 kg/m 2 but can also be considered in women with normal BMI. 12 Treatment is suggested to start at a low dose, with 500 mg increments once or twice per week, to minimize side effects, with suggested maximum dose 2.5 g in adults and 2 g ...
23 paź 2003 · This is the first systematic review and meta-analysis of randomised controlled trials in the use of metformin in treating polycystic ovary syndrome. Where metformin is used as a sole agent, ovulation is achieved in 46% of recipients compared with 24% in the placebo arm (NNT = 4.4)
1 gru 2022 · Metformin is typically the first-line treatment for patients with type 2 diabetes; it is not approved for use in prediabetes or PCOS, although it is often prescribed for treatment of these conditions.
Results. Significantly more women with PCOS by updated guidelines should be taking metformin than women with PCOS by previous guidelines. Using the old guidelines 12% of patients should be taking metformin which increased to 91% using the new guidelines (p<0.0001).
31 maj 2003 · Similarly, metformin treatment of patients with PCOS undergoing in-vitro fertilisation improved outcome. 46 women with clomiphene-resistant PCOS received daily metformin (1000–1500 mg) in half of 60 cycles before gonadotropin treatment.
