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METFORMIN. USE IN POLYCYSTIC OVARIAN SYNDROME. What is PCOS? Polycystic ovarian syndrome (PCOS) is a hormonal condition in women of reproductive age. It is believed that genetics, hormones and lifestyle factors can contribute to the development of PCOS. Some women with PCOS can have insulin resistance.
The purpose of this paper is to clarify some of the advice published about the use of metformin therapy for the management of infertility in women with PCOS. 2. Insulin resistance (IR) IR is defined as a reduced glucose response to a given amount of insulin and usually results from faults within the insulin receptor and post-receptor signalling.
Reducing insulin levels by weight loss, exercise or drugs results in a lowering of testosterone and an improvement of the symptoms of PCOS. Metformin is a drug that has been used in the treatment of diabetes for over 30 years. It acts by making the body more sensitive to insulin.
15 kwi 2014 · Metformin is an effective ovulation induction agent for non-obese women with PCOS and offers some advantages over other first line treatments for anovulatory infertility such as clomiphene. For clomiphene-resistant women, metformin alone or in combination with clomiphene is an effective next step.
1 gru 2022 · The use of metformin in the management of PCOS will be reviewed here. The clinical manifestations, diagnosis, and other treatment options for PCOS are reviewed separately.
14 lut 2022 · Insulin resistance (IR) plays an important role in the pathophysiology of PCOS; therefore, its treatment may benefit women with the syndrome. The main drug used for IR management is metformin (MT). We aim to review the literature on the use of metformin in women with PCOS.
23 paź 2003 · This is the first systematic review and meta-analysis of randomised controlled trials in the use of metformin in treating polycystic ovary syndrome. Where metformin is used as a sole agent, ovulation is achieved in 46% of recipients compared with 24% in the placebo arm (NNT = 4.4)
