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Metformin was the first insulin sensitising drug (ISD) to be used in PCOS to investigate the role of insulin resistance in the pathogenesis of the syndrome [Velazquez et al. 1994].
- PMC Free Article
The cumulative incidence of diabetes was lower in the...
- PubMed
The classification of diabetes mellitus and the tests used...
- PMC Free Article
16 wrz 2020 · Through quantitative synthesis, we found that as a drug that regulates the metabolism of overweight women with PCOS, metformin seems to have a partial effect, can reduce BMI and WC, and can reduce testosterone, FSH, LH, and LDL cholesterol.
14 lut 2022 · Metformin increases success rates and decreases complication rates when used as an adjunctive medication for ovulation induction during low complexity assisted reproduction treatments and during ovarian stimulation for in vitro fertilization in women with PCOS.
20 lis 2023 · Metformin should not be routinely used in pregnancy in PCOS but could be considered in some circumstances to reduce risk of preterm delivery or to limit excess gestational weight gain. Metformin does not prevent miscarriage, gestational diabetes, hypertension, preeclampsia, or macrosomia in PCOS. 5 , 20
Metformin therapy for PCOS Metformin inhibits the production of hepatic glucose, decreases lipid synthesis, increases fatty acid oxidation and inhibits gluconeogenesis resulting in a decrease in circulating insulin and glucose. 14 Metformin enhances insulin
Metformin increases success rates and decreases complication rates when used as an adjunctive medication for ovulation induction during low complexity assisted reproduction treatments and during ovarian stimulation for in vitro fertilization in women with PCOS.
9 cze 2015 · In PCOS, metformin reduces insulin resistance and inhibits ovarian androgen production via effects on steroidogenic acute regulatory protein and 17alpha-hydroxylase (Diamanti-Kandarakis et al., 2010; Viollet et al., 2012).
