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22 kwi 2024 · The severity of stiff person syndrome varies from person to person, but the two main symptoms are the same: Muscle stiffness - also called muscle rigidity, usually affects your back, chest, and abdomen and sometimes your arms and legs.
Stiff person syndrome (SPS) is a rare disorder, characterised by fluctuating rigidity and stiffness of the axial and proximal lower limb muscles, with superimposed painful spasms and continuous motor unit activity on electromyography.
6 kwi 2021 · aim is to improve symptoms. agents used in this condition include GABAergic agonists, such as diazepam or other benzodiazepines, steroids, plasmapheresis, and intravenous immunoglobulin (IVIG) Reference: Dalakas MC. Stiff person syndrome: Advances in pathogenesis and therapeutic interventions.
Core symptoms of SPSD include fluctuating muscle stiffness with superimposed spasms, often leading to a prominent gait disturbance and an exaggerated startle response (hyperekplexia).
Suggested major diagnostic criteria for SPS include stiffness in axial and limb muscles, painful spasms, and EMG confirmation of continuous motor unit activity in agonist and antagonist muscles. Minor criteria include positive antibodies in serum and clinical response to benzodiazepines.
People who have stiff person syndrome can experience severe muscle spasms and other unpleasant symptoms that can worsen without treatment. Stiff person syndrome is named after the symptoms that were originally described with the condition: episodes of muscles locking up and becoming stiff as a board.
10 cze 2024 · What are the symptoms of stiff person syndrome? The two main symptoms of stiff person syndrome are: Muscle stiffness or rigidity. Painful muscle spasms. Symptoms can develop at any age, but they most often begin in your 30s and 40s. Stiff person syndrome symptoms can spread to other areas of your body and/or get worse over time.
