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Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes.
Maternal treatment of paracetamol overdose should be as for the non-pregnant patient. There is evidence linking a delay in treating a pregnant patient with N-acetylcysteine (NAC) with increased fetotoxic effects. Treatment with NAC should not be withheld on the basis of pregnancy.
CONCLUSIONS: Pregnant women with acute APAP overdose should be treated early with IV NAC. Delayed therapy is associated with maternal and fetal hepatotoxicity. Overdose, in the presence or abscence of hepatotoxicity, may precipitate premature labor and fetal death.
7 maj 2024 · Acetaminophen poisoning is among the most common causes of medication-related poisoning and death. It may occur following an acute ingestion or through repeated ingestions of supratherapeutic amounts.
Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes.
Most patients with APAP overdose have minimal or nonspecific symptoms such as malaise, abdominal pain or nausea, and vomiting at presentation. A detailed medication history can help ascertain total APAP exposure but can be challenging in patients with polydrug overdose or advanced encephalopathy.
Acetaminophen is one of the most commonly used medications during pregnancy with an estimated 65% of pregnant women in the United States using it at least once. 1 Acetaminophen, an analgesic and antipyretic, is considered an appropriate treatment for headache, fever, and aches and pains during pregnancy. 2 While acetaminophen use in pregnancy ...
