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Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes.
Successful treatment of APAP overdose during pregnancy requires supportive care, early administration of IV NAC and a multidisciplinary team of specialists (intensivists, toxicologists, obstetricians and neonatologists) to optimize maternal-fetal outcome.
Maternal treatment of paracetamol overdose should be as for the non-pregnant patient. There is evidence linking a delay in treating a pregnant patient with N-acetylcysteine (NAC) with increased fetotoxic effects.
23 wrz 2021 · Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever.
20 sty 2024 · Acetaminophen is the only pain medication that has historically been thought to be safe for use during pregnancy and is recommended as a first-line agent by both the American College of...
Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes.
previously reports, 70.9% reported taking acetaminophen at least once during pregnancy, with most in the first trimester(58.6%).The primary indication for acetaminophen use was treatment of pain.
