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Acetaminophen (APAP) is the most common drug overdose in pregnancy. Available data regarding APAP overdose in pregnancy is limited to case reports and a small prospective case series. APAP has been demonstrated to cross the placenta and in toxic doses may harm the fetal and maternal hepatocytes.
To achieve optimal outcome following acetaminophen overdose, a systematic management approach is needed. This section outlines basic steps in managing acute acetaminophen overdose, consistent with FDA approved labeling of acetylcysteine. Flowchart 1 outlines this stepwise approach. 1. Initial Assessment
Maternal treatment of paracetamol overdose should be as for the non-pregnant patient. There is evidence linking a delay in treating a pregnant patient with N-acetylcysteine (NAC) with increased fetotoxic effects. Treatment with NAC should not be withheld on the basis of pregnancy.
7 maj 2024 · Acetaminophen poisoning is among the most common causes of medication-related poisoning and death. It may occur following an acute ingestion or through repeated ingestions of supratherapeutic amounts.
Successful treatment of APAP overdose during pregnancy requires supportive care, early administration of IV NAC and a multidisciplinary team of specialists (intensivists, toxicologists, obstetricians and neonatologists) to optimize maternal-fetal outcome.
A consensus statement that was recently published in the journal Nature Reviews Endocrinology claims that a growing body of research shows that prenatal exposure to paracetamol, or acetaminophen, may alter fetal development and increase the risks of neurodevelopmental, reproductive, and urogenital disorders. ACOG and obstetrician-gynecologists ...
20 sty 2024 · Acetaminophen is the only pain medication that has historically been thought to be safe for use during pregnancy and is recommended as a first-line agent by both the American College of...
