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Indications for thyroid function testing. 2.1 Introduction. 2.2 Screening for thyroid dysfunction. 2.2 Surveillance of thyroid function. 2.3 Monitoring of thyroid function . Hypothyroidism. 3.1 Primary hypothyroidism . 3.2 Subclinical (mild) hypothyroidism. 3.3 Secondary hypothyroidism. 3.4 Congenital hypothyroidism.
recommended reference ranges in the guidelines (0.4 – 4 mIU/L). Conversely, the risk of heart disease, stroke, broken bones and death was higher in hypothyroid patients with TSH levels outside the recommended reference range. Importantly, this range offers flexibility in treatment since patients may feel better at different TSH
[total and free thyroid hormones, TSH, thyroid autoantibodies (TRAb, TPOAb and TgAb) and thyroglobulin (Tg)] have dramatically improved clinical strategies for detecting and treating thyroid disorders.
Reference Range SI Reference Intervals Endocrine: Follicle-stimulating hormone Male: 4–25 mIU/mL 4–25 IU/L Female: premenopause 4–30 mIU/mL 4–30 IU/L midcycle peak 10–90 mIU/mL 10–90 IU/L postmenopause 40–250 mIU/mL 40–250 IU/L Luteinizing hormone Male: 6–23 mIU/mL 6–23 IU/L
The measurement of plasma TSH is the commonly accepted and most sensitive screening test for primary thyroid disorders, because the pituitary gland responds with great changes in its secretion, even to slight changes in the levels of free thyroid hormones.
A Thyroid function test (TFT) commonly refers to the quantitation of thyroid stimulating hormone (TSH) and circulating thyroid hormones in serum to assess the ability of the thyroid gland to produce and regulate thyroid hormone production.
The finding of an elevated TSH and low FT4 or FTI indicates primary hypothyroidism due to disease in the thyroid gland. A low TSH and low FT4 or FTI indicates hypothyroidism due to a problem involving the pituitary gland. A low TSH with an elevated FT4 or FTI is found in individuals who have hyperthyroidism.
