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Indications for thyroid function testing. 2.1 Introduction. 2.2 Screening for thyroid dysfunction. 2.2 Surveillance of thyroid function. 2.3 Monitoring of thyroid function . Hypothyroidism. 3.1 Primary hypothyroidism . 3.2 Subclinical (mild) hypothyroidism. 3.3 Secondary hypothyroidism. 3.4 Congenital hypothyroidism.
Tests Used to Detect Thyroid Dysfunction. Defining Ranges for Serum TSH. Individual’s range. • Much narrower than reference range. Lab reference range. • Defined by values in “normal” population. Target range. Goals for thyroxine treatment of specific conditions. Hypothyroidism: normalization of TSH within age-specific reference range.
The introduction of sensitive thyrotropin assays and free thyroid hormone measurements has simplified the interpretation of thyroid function tests. However, important pitfalls and difficult cases still exist. In this review, thyroid function test results are grouped into six different patterns.
The normal range of thyroid function tests is determined by measuring Free T4 and TSH levels in a population of healthy adults with no thyroid problems. Those results in the middle 95% are considered the normal range; the 2.5% above these levels and the 2.5% below these levels are considered abnormal.
Assessing serum levels of thyroid stimulating hormone (TSH) is the single most useful test for diagnosing thyroid dysfunction. If an individual’s TSH level is within the reference range...
Thyreotropin (TSH – Thyroid Stimulating Hormone) stimulates the production and secretion of the metabolically-active thyroid hormones, thyroxine (T4) and triiodothyronine (T3), by interacting with a specific receptor on the thyroid cell surface. TSH is composed of two non-covalently linked subunits, designated alpha and beta.
1 wrz 2013 · The upper TSH reference limit has progressively declined over the last decade thanks to more sensitive TSH assays, more accurate thyroid antibody tests, and a more accurate selection of the reference population.
