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A trough level can be pertinent when the concentration–effect relationship suggests that efficacy (or toxicity) of a drug is linked to the maintenance of blood concentrations above a predefined targeted concentration (glycopeptides, antiviral or antiretroviral drugs, for instance). From: Therapeutic Drug Monitoring, 2012
The trough levels are the most reliable measurement of drug elimination and more closely reflect the potential for drug accumulation in patients with renal failure. Knowing the potential a drug has for direct renal toxicity is important in patients with decreased renal function. Read more. View article. https://www.sciencedirect.
A trough is the lowest point of a wave, representing a position where the wave's displacement is at its minimum. This key feature is essential for understanding wave behavior, as it contrasts with the crest, which is the highest point.
Troughs are the regions of a wave where the wave displacement is negative, meaning the wave is below its resting position. The distance between two consecutive troughs is equal to the wavelength of the wave.
A trough level is drawn when the drug is at its lowest in the bloodstream, right before the next scheduled dose is given. Medications have a predicted reference range of normal values for peak and trough levels.
Trough: the lowest point of the wave. Wave height: the distance between the crest and the trough. Wavelength: the distance between two identical points on successive waves, for example crest to crest, or trough to trough.
