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10 maj 2024 · Four-fold or greater rise in serum varicella immunoglobulin G (IgG) antibody titer by any standard serologic assay between acute and convalescent sera. For both unvaccinated and vaccinated people, PCR is the most reliable method for confirming a VZV infection.
1.10 ISR or greater: Positive - Significant level of detectable varicella-zoster virus IgM antibody. Indicative of current or recent infection. However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection or immunization.
In contrast, famciclovir has a bioavailability of 77% after oral administration. It is used for antiviral therapy of zoster in immunocompetent adults and immunosuppressed patients from the age of 25 years. Similar to valaciclovir, famciclovir is not approved in childhood and adolescence.
The presence of detectable IgG-class antibodies indicates prior exposure to the varicella-zoster virus (VZV) through infection or immunization. Individuals testing positive are considered immune to varicella-zoster. Equivocal: AI 0.9-1.0
Acute infection can be confirmed by VZV-specific serum IgM titers, but antigen detection techniques are usually faster and more reliable. Patients with herpes zoster are VZV-seropositive at the time of disease onset, but most show a significant rise in antibody titer during the convalescent phase.
15 paź 2022 · Go to: Chickenpox or varicella is a contagious disease caused by the varicella-zoster virus (VZV). The virus is responsible for chickenpox (usually primary infection in non-immune hosts) and herpes zoster or shingles (following reactivation of latent infection). Chickenpox results in a skin rash forming small, itchy blisters that scabs over.
31 maj 2024 · Adults, pregnant women, immunosuppressed patients, and neonates are at high risk of complications from varicella, including pneumonia, neurological sequelae, hepatitis, secondary bacterial infection, and death. Patients in high-risk categories should receive treatment with antiviral therapy.
