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Acute infection can be confirmed by VZV-specific serum IgM titers, but antigen detection techniques are usually faster and more reliable. Patients with herpes zoster are VZV-seropositive at the time of disease onset, but most show a significant rise in antibody titer during the convalescent phase.
In contrast, famciclovir has a bioavailability of 77% after oral administration. It is used for antiviral therapy of zoster in immunocompetent adults and immunosuppressed patients from the age of 25 years. Similar to valaciclovir, famciclovir is not approved in childhood and adolescence.
Treatment options are based on the patient's age, immune state, duration of symptoms, and presentation. Several studies indicate that antiviral medications decrease symptom duration and the...
10 maj 2024 · This varicella-zoster virus (VZV) laboratory testing information applies to testing and diagnosis of primary VZV infection (varicella) and reactivation (herpes zoster). Polymerase chain reaction (PCR) is the most helpful laboratory test for confirming cases of varicella and herpes zoster.
15 paź 2022 · People at risk of developing complications and who have had significant exposure may be given intramuscular varicella-zoster immune globulin, a preparation containing high titers of antibodies to the varicella-zoster virus, to help prevent the disease.
12 lut 2016 · Acute VZV infection is diagnosed by detection of the virus (Table 1). The method of choice is polymerase chain reaction (PCR) to detect viral genomes in vesicle fluids, cerebrospinal fluids, tissues, bronchoalveolar lavages, EDTA blood, or amniotic fluids [23].
28 lut 2024 · Classified within the "Opportunistic Infections and Co-infections" treatment category, VZIG has proven effective in mitigating the severity of varicella in susceptible patients. This educational activity explores key aspects of VZIG therapy, encompassing indications, contraindications, mechanisms of action, and potential adverse effects.
