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14 sie 2024 · In this review, we will detail the history of vaccine development using spirochetal outer surface protein A (OspA) and newer strategies—targeting the tick—to protect against B burgdorferi transmission.
17 lis 2021 · The primary objective of this study was to design and evaluate the effect of an mRNA-LNP–based vaccine composed of 19 tick salivary proteins as a potential tool to prevent tick-borne diseases.
25 cze 2019 · Two primary interests have driven research into tick salivary secretions: the search for suitable pathogen transmission blocking or “anti-tick” vaccine candidates and the search for novel therapeutics derived from tick salivary components.
22 lis 2021 · A Lyme disease vaccine based on mRNA targets tick saliva proteins, induces tick resistance, and prevents transmission of Lyme disease agent.
We searched PubMed, Science Direct, Elsevier and other sites for publications regarding tick saliva and its effects on cancer cells and angiogenesis. Our aim was to compile a list of molecules with potential for host adaptation and for the development of new cancer treatment drugs.
29 paź 2024 · In this study, we demonstrate a dual role of a specific Ixodes tick protein disulfide isomerase (PDI) in inhibiting the ability of the Lyme disease agent to colonize ticks and also in enhancing the initial stage of spirochete infection of mice.
17 lis 2021 · Costa et al. identified three vaccine antigens involved with hematophagy including a Kunitz domain protein, a ‘basic tail’ protein (PFAM domain TSGP1), and an 8.9 kDa polypeptide protein (Von-Willebrand factor type c domain) previously shown to be common in tick saliva.
