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The mononuclear phagocyte system is part of both humoral and cell-mediated immunity. The mononuclear phagocyte system has an important role in defense against microorganisms, including mycobacteria, fungi, bacteria, protozoa, and viruses.
1 sie 2005 · Located in the abdomen, directly beneath the diaphragm, and connected to the stomach, the spleen is the body's largest filter of the blood 1, 2. In essence, the spleen is organized as a 'tree' of...
APCs unique to the spleen regulate the T and B cell response to these antigenic targets in the blood. This review will focus on cell types, cell organization and immunologic functions specific to the spleen, and how these impact initiation of adaptive immunity to systemic blood-borne antigens.
26 lis 2024 · These cells serve as a link between the bodily tissues and the innate and adaptive immune systems, as they present antigen to T-cells, one of the key cell types of the adaptive immune system. Figure: A Phagocyte in Action: Neutrophil engulfing anthrax bacteria. Taken with a Leo 1550 scanning electron microscope. Scale bar is 5 micrometers.
2 mar 2019 · APCs specific to the spleen regulate the T and B cell response to these antigenic targets in the blood. This review will focus on cell types, cell organization, and immunologic functions specific to the spleen and how these affect initiation of adaptive immunity to systemic blood-borne antigens.
In this review, we examine spleen functions and mechanisms of actions at the cellular and molecular levels, which are thought to regulate innate and adaptive immunity, control antigen toler-ance, and either protect the host or contribute to diseases.
spleen: A ductless vascular gland that destroys old red blood cells, removes debris from the bloodstream, acts as a reservoir of blood, and produces lymphocytes. white pulp: The part of the spleen where lymphocytes are maintained in a similar way as in lymph nodes. red pulp: The site of blood filtration in the spleen.
