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25 gru 2018 · THC-COOH is formed when liver enzymes oxidise hydroxy-THC. It’s the main metabolite tested for in urine and blood screenings due to its long half-life.
28 cze 2020 · THC-COOH is a lipid-soluble substance that forms in the body after THC interacts with the liver enzymes. It is the main target of drug tests for cannabis users, as it can stay in the fat cells for weeks or months after consumption.
11-Nor-9-carboxy-Δ9-tetrahydrocannabinol (11-COOH-THC or THC-COOH), often referred to as 11-nor-9-carboxy-THC or THC-11-oic acid, is the main secondary metabolite of tetrahydrocannabinol (THC) which is formed in the body after cannabis is consumed.
29 wrz 2016 · The primary psychoactive agent in Cannabis, ∆-9-tetrahydrocannabinol (THC), has a naturally occurring inactive precursor tetrahydrocannabinolic acid, often referred to as THC acid, or THCa, THC carboxy, or 2-COOH-THC (see Fig. Fig.1). 1). The carboxyl group in the inactive precursor is on carbon #2.
THC, the main psychoactive component of cannabis, may only be detectable in saliva and oral fluid for 2–24 hours in most cases. [8] [9] The main metabolite excreted in the urine is 11-Nor-9-carboxy-THC, also known as THC-COOH. Most cannabis drug tests yield a positive result when the concentration of THC-COOH in urine exceeds 50 ng/mL. [10]
11 cze 2024 · THC-COOH is the primary metabolite detected in urine and blood screenings for cannabis use. While its presence indicates previous cannabis consumption, it doesn't prove current impairment. How Does THC-COOH Relate to Drug Testing?
Among the major metabolites ( 9-THC,11-OH-THC, and THCCOOH), THCCOOH is the primary glucuronide conjugate in urine, while 11-OH-THC is the predominant form in feces (51, 69). Since 9 -THC is extremely soluble in lipids, it results in tubular re-absorption, leading to low renal excretion of unchanged drug.
