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Flame phase 1: Dodge verticallyFlame phase 2: Wait for flamethrower, use discs or knife if you have themLaser phase 1: Stay diagonal to confuse the predicted...
Melee and ranged users should substitute in a Frost Breastplate to increase damage output and defense without sacrificing anything important. Titanium armor is a defensive alternative for Adamantite Armor, the Titanium Barrier / Shadow Dodge buff increases survivability.
Twins as melee is a pain in the ass. Getting close to either one is dangerous. I recommend the shadowflame knife for a bit more range and, because you won't have to get so close, reforge your accessories to menacing.
Melee and ranged users should substitute in a Frost Breastplate to increase damage output and defense without sacrificing anything important. If more offense is desired, Mythril Greaves or Spider Greaves (Desktop, Console, Old-gen console and Mobile versions) should be substituted into the leg slot.
Using the megashark + ichor bullets makes the fight way easier. Focus on one of them at a time and try not to hit the other until you fully defeat one of them (you don’t want to fight both of them in their second stage). Notes: Retinazer is the red one that shoots lasers.
get shadowflame knife (best early "melee" weapon) and keep your distance. Best accesories for melee: brain of confusion, charm of myths, worm scarf, frozen shell, wings, amphibian boots and warrior emblem.
The Twins are two separate flying entities, Retinazer and Spazmatism, connected by a tendril, each with its own attack pattern and life count. Both must be killed in order to defeat the boss. The Twins can be summoned manually using a Mechanical Eye at night (7:30 PM to 4:30 AM).