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23 paź 2023 · Smoom and colleagues developed a mouse strain with human-size telomeres. This mouse, termed Telomouse, is therefore an invaluable tool for studying human aging and cancer.
14 lut 2022 · Mouse studies indicate that telomere dysfunction can recapitulate IPF features. Mice with short telomeres induced by knockout of telomerase components show TAFs, inflammation and fibrosis...
28 lis 2010 · Our data establish that telomerase reactivation in adult mice with telomere dysfunction can restore SVZ neurogenesis and, consistent with its role in sustaining new olfactory bulb neurons,...
1 lis 2023 · TERT treatment results in telomere lengthening, thereby increasing the number of Ki67 and pH3-positive myocardial cells, resulting in a shift in gene expression towards regenerative characteristics in newborn mice [101].
Together, these results constitute a proof-of-principle of a role of TERT in delaying physiological aging and extending longevity in normal mice through a telomerase-based treatment, and demonstrate the feasibility of anti-aging gene therapy. Keywords: AAV9, aging, gene therapy, health span, TERT.
3 kwi 2017 · Results obtained in mouse models with telomerase gene therapy as a treatment for aging-associated diseases and telomere syndromes, as well as shelterin chemical inhibition as anticancer therapy treatment, constitute promising opportunities for further clinical development.
As targeting removal of senescent cells with senolytics has been shown to improve the age-related phenotypes and vascular pathology seen in old rodents, 23 several recent clinical trials have been initiated in age-related diseases or other diseases characterized by telomere dysfunction and an abundance of senescent cells. 68,69 Thus, a new ...
