Search results
Together, these results constitute a proof-of-principle of a role of TERT in delaying physiological aging and extending longevity in normal mice through a telomerase-based treatment, and demonstrate the feasibility of anti-aging gene therapy. Keywords: AAV9, aging, gene therapy, health span, TERT.
3 kwi 2017 · Results obtained in mouse models with telomerase gene therapy as a treatment for aging-associated diseases and telomere syndromes, as well as shelterin chemical inhibition as anticancer therapy treatment, constitute promising opportunities for further clinical development.
1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.
15 maj 2012 · Promoting healthspan in mice using a telomerase gene therapy. Delivery of telomerase (TERT) using rAAV suppresses aging associated telomere erosion and extends short telomeres in a variety of mouse tissues. Consequently, animals display improved healthspan and extended lifespan.
17 paź 2019 · We found that hyper-long telomere mice showed a reduction of almost 50% in the number of mice that developed tumors compared to the normal telomere length control mice, although this...
Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction.
24 cze 2014 · Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1−/− tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative...
