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24 cze 2014 · Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1−/− tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative...
28 lis 2010 · Ronald DePinho and colleagues now show that reactivation of endogenous telomerase in mice extends telomeres, reduces DNA damage signalling, allows resumption of proliferation in quiescent...
Based on this notion, we tested the effects of a telomerase gene therapy in adult (1 year of age) and old (2 years of age) mice. Treatment of both groups of mice with an AAV of wide tropism expressing mouse telomerase (mTERT) demonstrated remarkable beneficial effects on health and fitness, improving several molecular biomarkers of aging.
17 paź 2019 · We found that hyper-long telomere mice showed a reduction of almost 50% in the number of mice that developed tumors compared to the normal telomere length control mice, although this...
Here Jurk et al. use a mouse model of chronic, low-grade inflammation to support a model by which such inflammation promotes a vicious cycle of oxidative stress, telomere dysfunction and cell senescence that accelerates the ageing process. Many age-related diseases and ageing itself are closely associated with low-level chronic inflammation 1, 2.
1 lis 2023 · The link between telomere dysfunction, hallmarks of aging and incidence of age-related diseases has spawned interest in telomerase recovery therapy as a potential anti-aging strategy.
19 paź 2022 · Telomere restoration therapy extends the lifespan of aged mice by 20%. Our telomeres shorten as we age, causing our DNA repair systems to malfunction. In response, affected cells convert to a senescent state, secreting molecules known as the senescence-associated secretory phenotype (SASP).
