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24 cze 2014 · Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1−/− tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue...
Based on this notion, we tested the effects of a telomerase gene therapy in adult (1 year of age) and old (2 years of age) mice. Treatment of both groups of mice with an AAV of wide tropism expressing mouse telomerase (mTERT) demonstrated remarkable beneficial effects on health and fitness, improving several molecular biomarkers of aging.
17 paź 2019 · We found that hyper-long telomere mice showed a reduction of almost 50% in the number of mice that developed tumors compared to the normal telomere length control mice, although this...
14 lut 2022 · Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere...
5 sie 2024 · Telomerase substrate that induces telomere dysfunction. Reduced tumor growth and improved survival in mouse models of glioblastoma and melanoma. Preclinical studies only, showing promise for future clinical trials.
Telomere dysfunction can initiate and maintain inflammation on several levels. First, telomere dysfunction provokes cellular senescence, which stimulates production and secretion of interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNFα), among other inflammatory factors (Coppe et al., 2010).
14 sty 2021 · Treatment of telomere-dysfunctional mice with a YAP1 inhibitor, caspase-1 inhibitor, or antibiotics in vivo or reactivation of telomerase in the intestinal compartment leads to a reduction in cleavage of procaspase-1 to caspase-1 and in production of mature IL-18, consequently reducing tissue inflammation.
