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24 cze 2014 · Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1−/− tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative...
17 paź 2019 · In agreement with longer telomeres, hyper-long telomere mice also showed a significantly lower accumulation of short telomeres at old age compared with the age-matched control mice (Fig. 5a–f...
Based on this notion, we tested the effects of a telomerase gene therapy in adult (1 year of age) and old (2 years of age) mice. Treatment of both groups of mice with an AAV of wide tropism expressing mouse telomerase (mTERT) demonstrated remarkable beneficial effects on health and fitness, improving several molecular biomarkers of aging.
28 lis 2010 · Our data establish that telomerase reactivation in adult mice with telomere dysfunction can restore SVZ neurogenesis and, consistent with its role in sustaining new olfactory bulb neurons,...
1 lut 2008 · This review aims to provide an introduction to the biology of telomeres and telomerase and to discuss some of the telomere/telomerase directed therapeutic methodologies currently under development which may be of benefit to the canine cancer patient.
1 mar 2023 · DHA might decelerate the telomere shortening in ageing Terc −/− mice through ameliorating mitochondrial dysfunction, decreasing oxidative stress, further reducing DNA damage, and ultimately alleviating telomere dysfunction.
Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1−/− tissues is blocked by anti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative potential.
